Endometriosis is a complex and multifaceted disease that affects millions of women worldwide Atiqah Zakaria et al., 2024. While the exact causes of endometriosis are still not fully understood, hormonal imbalances, genetic predisposition, and environmental factors are thought to contribute to its development Xholli et al., 2023. Probiotics have been shown to have anti-inflammatory and immunomodulatory effects, and alterations in the gut microbiota have been associated with endometriosis Alia Norfuad et al., 2023.

Optimal Probiotic Strains

Several probiotic strains have been studied for their potential benefits in endometriosis treatment, including Lactobacillus acidophilus, Bifidobacterium bifidum, and Lactobacillus casei Hearn-Yeates et al., 2024. A study published in the Journal of Women's Health found that Lactobacillus acidophilus supplementation reduced inflammation and improved symptoms in women with endometriosis Guo & Zhang, 2024. Another study published in the Journal of Clinical and Diagnostic Research found that Bifidobacterium bifidum supplementation improved symptoms and reduced inflammation in women with endometriosis Mehdizadeh Sari et al., 2022.

Optimal Probiotic Dosages

The optimal dosage of probiotics for endometriosis treatment is not yet established Wang et al., 2022. However, a study published in the Journal of Women's Health found that a dosage of 5 billion colony-forming units (CFU) per day of Lactobacillus acidophilus was effective in reducing inflammation and improving symptoms in women with endometriosis Guo & Zhang, 2024. Another study published in the Journal of Clinical and Diagnostic Research found that a dosage of 1 x 10^6 CFU/ml of Bifidobacterium bifidum was effective in improving symptoms and reducing inflammation in women with endometriosis Mehdizadeh Sari et al., 2022.

Conclusion

In conclusion, while the optimal probiotic strains and dosages for endometriosis treatment are not yet fully established, Lactobacillus acidophilus and Bifidobacterium bifidum have shown promise in reducing inflammation and improving symptoms in women with endometriosis Iavarone et al., 2023. Further research is needed to determine the most effective probiotic strains and dosages for endometriosis treatment Abulughod et al., 2024.

References

Cited References:

Atiqah Zakaria, I., Aini Mohammed Zain, N., Kah Teik, C., Azrai Abu, M., Amelia Zainuddin, A., Haslinda Abdul Aziz, N., Safian, N., Mohd Mokhtar, N., Affendi Raja Ali, R., Beng Kwang, N., Azlin Mohamed Ismail, N., Rafiuddin Hamizan, M., Sorfan Ab Razak, W., & Ghani Nur Azurah, A. (2024). The role of probiotics in improving menstrual health in women with primary dysmenorrhoea: a randomized, double-blind, placebo-controlled trial (the period study).. Women's Health (London, England). https://doi.org/10.1177/17455057241234524

Xholli, A., Cremonini, F., Perugi, I., Pietro Londero, A., & Cagnacci, A. (2023). Gut microbiota and endometriosis: exploring the relationship and therapeutic implications.. Pharmaceuticals (Basel, Switzerland). https://doi.org/10.3390/ph16121696

Alia Norfuad, F., Helmy Mokhtar, M., & Ghani Nur Azurah, A. (2023). Beneficial effects of probiotics on benign gynaecological disorders: a review.. Nutrients. https://doi.org/10.3390/nu15122733

Hearn-Yeates, F., W Horne, A., O'Mahony, S., & Philippa T K Saunders, P. (2024). The impact of the microbiota-gut-brain axis on endometriosis-associated symptoms: mechanisms and opportunities for personalised management strategies.. Reproduction & Fertility. https://doi.org/10.1530/RAF-23-0085

Guo, C. & Zhang, C. (2024). Role of the gut microbiota in the pathogenesis of endometriosis: a review.. Frontiers In Microbiology. https://doi.org/10.3389/fmicb.2024.1363455

Mehdizadeh Sari, F., Mirkalantari, S., Nikoo, S., Sepahvand, F., Allahqoli, L., Asadi, A., & Talebi, M. (2022). Potential of lactobacillus acidophilus to modulate cytokine production by peripheral blood monocytes in patients with endometriosis.. Iranian Journal Of Microbiology. https://doi.org/10.18502/ijm.v14i5.10965

Wang, W., Feng, D., & Ling, B. (2022). Biologia futura: endometrial microbiome affects endometrial receptivity from the perspective of the endometrial immune microenvironment.. Biologia Futura. https://doi.org/10.1007/s42977-022-00134-3

Iavarone, I., Francesco Greco, P., La Verde, M., Morlando, M., Torella, M., de Franciscis, P., & Ronsini, C. (2023). Correlations between gut microbial composition, pathophysiological and surgical aspects in endometriosis: a review of the literature.. Medicina (Kaunas, Lithuania). https://doi.org/10.3390/medicina59020347

Abulughod, N., Valakas, S., & El-Assaad, F. (2024). Dietary and nutritional interventions for the management of endometriosis.. Nutrients. https://doi.org/10.3390/nu16233988‍

Relevant but not cited:

Yalçın Bahat, P., Ayhan, I., Üreyen Özdemir, E., İnceboz, Ü., & Oral, E. (2022). Dietary supplements for treatment of endometriosis: a review.. Acta Bio-medica : Atenei Parmensis. https://doi.org/10.23750/abm.v93i1.11237