Treatment options for endometriosis can be broadly categorised into medical, surgical, and complementary therapies Hussam Al Deen Al Hussaini et al., 2025.

Medical Treatment Options

Medical treatment options for endometriosis aim to reduce symptoms, slow disease progression, and improve quality of life Vannuccini et al., 2021. The most commonly used medical treatments include:

Hormonal therapies

Hormonal therapies, such as combined oral contraceptives, progestins, and gonadotropin-releasing hormone (GnRH) agonists, are effective in reducing endometriosis symptoms by suppressing ovarian function and reducing menstrual flow Vannuccini et al., 2021.

Pain management

Pain relief medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and opioids, are often used to manage endometriosis-related pain Zubedat et al., 2024.

Selective progesterone receptor modulators

These medications, such as ulipristal acetate, have been shown to be effective in reducing endometriosis symptoms and improving quality of life Vannuccini et al., 2021.

Surgical Treatment Options

Surgical treatment options for endometriosis aim to remove endometrial lesions, scar tissue, and adhesions S Klebanoff et al., 2021. The most commonly used surgical treatments include:

Laparoscopic surgery

Laparoscopic surgery is a minimally invasive procedure that involves removing endometrial lesions and scar tissue through small incisions in the abdomen S Klebanoff et al., 2021.

Hysterectomy

Hysterectomy, or the removal of the uterus, may be considered in severe cases of endometriosis where other treatments have failed Pécout et al., 2020.

Complementary Treatment Options

Complementary treatment options for endometriosis aim to alleviate symptoms and improve quality of life F Meresman et al., 2020. The most commonly used complementary treatments include:

Acupuncture

Acupuncture has been shown to be effective in reducing endometriosis-related pain and improving quality of life Zubedat et al., 2024.

Herbal supplements

Certain herbal supplements, such as turmeric and ginger, have anti-inflammatory properties and may be beneficial in reducing endometriosis symptoms F Meresman et al., 2020.

Dietary changes

Dietary changes, such as increasing omega-3 fatty acid intake and reducing gluten consumption, may be beneficial in reducing endometriosis symptoms F Meresman et al., 2020.

Multidisciplinary Approach

A multidisciplinary approach to endometriosis treatment is essential, as it involves a team of healthcare providers working together to develop a comprehensive treatment plan Pickett et al., 2023. This approach may include:‍‍

Pain management specialists

Pain management specialists can help develop a comprehensive pain management plan Zubedat et al., 2024.

Fertility specialists

Fertility specialists can help women with endometriosis achieve pregnancy L Newmark et al., 2021.

Mental health professionals

Mental health professionals can help women with endometriosis manage the emotional and psychological aspects of the disease Pickett et al., 2023.

‍

Conclusion

In conclusion, treatment options for endometriosis are diverse and depend on the individual's symptoms, disease severity, and reproductive goals Hussam Al Deen Al Hussaini et al., 2025. A comprehensive treatment approach that incorporates medical, surgical, and complementary therapies is essential for improving quality of life and enhancing fertility L Newmark et al., 2021.

References

Cited References:

Hussam Al Deen Al Hussaini, H., Ebtesam Saleem Eid Alatawi, E., Jenan Ali J Shabani, J., Maryam Isa Hasan Edhrabooh, M., Shaikha Abduljalil Abdulla Alhawaj, S., Sayed Almahfoodh, M., Yaseen Alsamiri, H., Reda AlMaatoug, A., Maryam Ismail M Hayderali, M., & Ramzi Almousa, M. (2025). Management of endometriosis-related pain: comparing the effectiveness of hormonal therapy, surgical interventions, and complementary therapies.. Cureus. https://doi.org/10.7759/cureus.75590

L Newmark, A., E Luciano, D., Ulrich, A., & A Luciano, A. (2021). Medical management of endometriosis.. Minerva Obstetrics And Gynecology. https://doi.org/10.23736/S2724-606X.21.04776-X

Vannuccini, S., Clemenza, S., Rossi, M., & Petraglia, F. (2021). Hormonal treatments for endometriosis: the endocrine background.. Reviews In Endocrine & Metabolic Disorders. https://doi.org/10.1007/s11154-021-09666-w

Zubedat, A., Liebergall-Wischnitzer, M., Solnica, A., Zusman, N., & Dior, U. (2024). An integrative approach for endometriosis-related pain.. Western Journal Of Nursing Research. https://doi.org/10.1177/01939459241283018

S Klebanoff, J., Inaty, D., Rahman, S., Habib, N., Bendifallah, S., Marc Ayoubi, J., & N Moawad, G. (2021). Appropriate surgical management of ovarian endometrioma: excision or drainage?. Hormone Molecular Biology And Clinical Investigation. https://doi.org/10.1515/hmbci-2020-0067

Pécout, M., Jean Dit Gautier, E., Doucède, G., Collinet, P., & Rubod, C. (2020). Pelvic endometriosis: refer to the surgeon at the right moment: pelvic endometriosis: when refer to the surgeon?. Journal Of Gynecology Obstetrics And Human Reproduction. https://doi.org/10.1016/j.jogoh.2020.101701

F Meresman, G., Götte, M., & W Laschke, M. (2020). Plants as source of new therapies for endometriosis: a review of preclinical and clinical studies.. Human Reproduction Update. https://doi.org/10.1093/humupd/dmaa039

Pickett, C., G Foster, W., & Agarwal, S. (2023). Current endometriosis care and opportunities for improvement.. Reproduction & Fertility. https://doi.org/10.1530/RAF-22-0091‍

Relevant but not cited:

Greygoose, E., Metharom, P., Kula, H., K Seckin, T., A Seckin, T., Ayhan, A., & Yu, Y. (2025). The estrogen-immune interface in endometriosis.. Cells. https://doi.org/10.3390/cells14010058

García-Gómez, E., Ricardo Vázquez-Martínez, E., Reyes-Mayoral, C., Paul Cruz-Orozco, O., Camacho-Arroyo, I., & Cerbón, M. (2020). Regulation of inflammation pathways and inflammasome by sex steroid hormones in endometriosis.. Frontiers In Endocrinology. https://doi.org/10.3389/fendo.2019.00935

Krygere, L., Jukna, P., Jariene, K., & Drejeriene, E. (2025). Diagnostic potential of cytokine biomarkers in endometriosis: challenges and insights.. Biomedicines. https://doi.org/10.3390/biomedicines12122867

Rathod, S., Shanoo, A., & Acharya, N. (2024). Endometriosis: a comprehensive exploration of inflammatory mechanisms and fertility implications.. Cureus. https://doi.org/10.7759/cureus.66128

Chou, Y., Chen, M., Chen, P., Chang, C., Yu, M., Chen, Y., Tsai, E., Tsai, S., Kuo, W., & Tzeng, C. (2021). Integration of genome-wide association study and expression quantitative trait locus mapping for identification of endometriosis-associated genes.. Scientific Reports. https://doi.org/10.1038/s41598-020-79515-4

Lalami, I., Abo, C., Borghese, B., Chapron, C., & Vaiman, D. (2021). Genomics of endometriosis: from genome wide association studies to exome sequencing.. International Journal Of Molecular Sciences. https://doi.org/10.3390/ijms22147297

Vallée, A., Ceccaldi, P., Carbonnel, M., Feki, A., & Ayoubi, J. (2023). Pollution and endometriosis: a deep dive into the environmental impacts on women's health.. BJOG : An International Journal Of Obstetrics And Gynaecology. https://doi.org/10.1111/1471-0528.17687

Coiplet, E., Courbiere, B., Agostini, A., Boubli, L., Bretelle, F., & Netter, A. (2022). Endometriosis and environmental factors: a critical review.. Journal Of Gynecology Obstetrics And Human Reproduction. https://doi.org/10.1016/j.jogoh.2022.102418

Momenimovahed, Z., Salehiniya, H., Allahqoli, L., S Laganà, A., Mazidimoradi, A., Moawad, G., Gitas, G., & Alkatout, I. (2024). Effects of herbal compounds on various aspects of endometriosis treatment: a systematic review.. European Review For Medical And Pharmacological Sciences. https://doi.org/10.26355/eurrev_202405_36182

Evans, S., Villegas, V., Dowding, C., Druitt, M., O'Hara, R., & Mikocka-Walus, A. (2021). Treatment use and satisfaction in australian women with endometriosis: a mixed-methods study.. Internal Medicine Journal. https://doi.org/10.1111/imj.15494

Bień, A., Pokropska, A., Grzesik-Gąsior, J., Korżyńska-Piętas, M., Zarajczyk, M., Rzońca, E., & Jurek, K. (2024). Clinical factors affecting the quality of life of women with endometriosis.. Journal Of Advanced Nursing. https://doi.org/10.1111/jan.16607

Baczek, G., Mietus, M., Klimanek, J., Tataj-Puzyna, U., Sienkiewicz, Z., Dykowska, G., Duda-Zalewska, A., & Teliga-Czajkowska, J. (2024). The impact of endometriosis on the quality of women's life.. Ginekologia Polska. https://doi.org/10.5603/gpl.93995

Zhu, T., Marschall, H., E Hansen, K., W Horne, A., Saraswat, L., T Zondervan, K., A Missmer, S., Hummelshoj, L., Bokor, A., S Østrup, C., Melgaard, A., & Rytter, D. (2025). Consensus on symptom selection for endometriosis questionnaires: a modified e-delphi study.. BJOG : An International Journal Of Obstetrics And Gynaecology. https://doi.org/10.1111/1471-0528.18066

Ellis, K., Munro, D., & Wood, R. (2022). The experiences of endometriosis patients with diagnosis and treatment in new zealand.. Frontiers In Global Women's Health. https://doi.org/10.3389/fgwh.2022.991045